Depression: Esketamine trial leaves ‘more questions than answers’

A phase 3 clinical trial testing esketamine nasal spray in the treatment of severe depression found the spray mostly safe and effective. The findings led to the recent FDA approval of this treatment. Despite this, other researchers caution that “more questions than answers” remain. A phase 3 clinical trial found esketamine nasal spray safe and […]

Researchers close in on a new depression mechanism

One key characteristic of clinical depression is anhedonia, the complete lack of pleasure in things and activities that used to be rewarding. A new study in rats has now uncovered an important biological factor that contributes to this state. Researchers have found a new ‘key player’ in depression, and the discovery could lead to therapies […]

Low-amp electroconvulsive therapy may relieve suicidal thoughts

New research compares lower amplitude electroconvulsive therapy with standard amplitude for the treatment of suicidal ideation and finds that the former relieves suicidal thoughts without affecting cognitive or memory function. Suicidal ideation primarily tends to affect individuals aged between 10 and 34 years. In 2017, there were more than 47,000 cases of suicide in the […]

Lack of motivation: Does inflammation alter brain systems?

Researchers from Emory University examine new evidence about how low-grade inflammation could impact a person’s level of motivation. This may also have implications for the treatment of some cases of depression. Researchers are taking a closer look at evidence directly connecting inflammation with a lack of motivation. The idea that depression or symptoms of depression […]