Early deaths from childhood cancer up to 4 times more common than previously reported

Treatments for childhood cancers have improved to the point that 5-year survival rates are over 80 percent. However, one group has failed to benefit from these improvements, namely children who die so soon after diagnosis that they are not able to receive treatment, or who receive treatment so late in the course of their disease […]

A new way to reset gene expression in cancer cells shows promise for leukemia treatment

New findings from Rockefeller University researchers could guide the development of potent combination therapies that deliver more effective and durable treatment of leukemia. In recent work published in Nature, they show it’s possible to deactivate cellular programs involved in tumor growth by disrupting a protein that regulates genes. At the center of this research are […]

AML study correlates gene mutations with 34 disease subgroups

A large, new study of adults with acute myeloid leukemia (AML) correlates 80 cancer-related gene mutations with five subtypes of AML, which are defined by the presence of specific chromosomal abnormalities. The findings might help guide mutation testing and treatment decisions in the future. Led by researchers at The Ohio State University Comprehensive Cancer Center […]

Method may help myeloma patients avoid painful biopsies

Multiple myeloma is a cancer of the plasma cells, which are white blood cells produced in bone marrow that churn out antibodies to help fight infection. When plasma cells become cancerous, they produce abnormal proteins, and the cells can build up in bone marrow, ultimately seeping into the bloodstream. The disease is typically diagnosed through […]

Global inequalities in survival for childhood leukaemia persist, highlighting need for better care

Although global inequalities in survival from childhood leukaemia have narrowed, they still persist with five-year survival in some countries nearly twice as high as in others for children diagnosed during 2005-2009, according to a study published in The Lancet Haematology. While survival has increased in many countries, five-year survival for acute lymphoblastic leukaemia (ALL) in […]

New study offers hope for more effective treatment of leukemia

The discovery of a protein signature that is highly predictive of leukemia could lead to novel treatments of the leading childhood cancer, according to new study showing that competition among certain proteins causes an imbalance that leads to leukemia. The new study in the journal Nature Immunology reveals that the activation of a protein known […]

Scientists create leukaemia online tool to aid global search for cure

Finding a cure for a rare type of blood cancer could be accelerated by a new virtual platform that allows researchers easy access to data from patient samples generated by laboratories around the world. LEUKomics, which has been launched by scientists at the University of Glasgow and the University of Melbourne, is a comprehensive database […]

‘Outstanding’ results announced from new blood cancer study

Scientists have described new results of a blood cancer study as ‘outstanding’ in tackling previously untreatable forms of chronic lymphocytic leukaemia (CLL). The advance led by a team from the University of Leicester and University Hospitals of Leicester NHS Trust, within the Hope Clinical Trials Facility, focused on treating patients with CLL. It follows on […]

FDA approves new combination treatment for acute myeloid leukemia

The U.S. Food and Drug Administration has approved Rydapt (midostaurin) for the treatment of adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3, in combination with chemotherapy. The drug is approved for use with a companion diagnostic, the LeukoStrat CDx FLT3 Mutation Assay, which is used to […]